SLK Gene Summary [Human]
Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLK |
| Official Name | STE20 like kinase [Source:HGNC Symbol;Acc:HGNC:11088] |
| Ensembl ID | ENSG00000065613 |
| Bio databases IDs | |
| Aliases | STE20 like kinase |
| Synonyms | 9A2, bA16H23.1, Etk4, KIAA0204, LOSK, mKIAA0204, mSLK, se20-9, SK2, SMAK, STE20-like kinase, STK2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- polo kinase kinase
- Protein kinase (unclassified specificity)
- protein kinase
- AT1-46 homology domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the SLK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- phosphorylation in
- migration
- activation in
- organization
- apoptosis
- proliferation
- necrosis
- disassembly
- adhesion
- mesenchymal motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cell cortex
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of focal adhesion assembly
- apoptotic process
- protein autophosphorylation
- regulation of apoptotic process
- cytoplasmic microtubule organization
- regulation of cell migration
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cell leading edge
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- cadherin binding
- protein serine/threonine kinase activity