GSTO2 Gene Summary [Human]
The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | GSTO2 |
| Official Name | glutathione S-transferase omega 2 [Source:HGNC Symbol;Acc:HGNC:23064] |
| Ensembl ID | ENSG00000065621 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase omega 2 |
| Synonyms | 1700020F09RIK, bA127L20.1, glutathione S-transferase omega 2, glutathione S-transferase ω 2, GSTO 2-2, LOC100909560, LOC102724376, LOC103690044 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSTO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutathione dehydrogenase (ascorbate)
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the GSTO2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSTO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione metabolic process
- cellular response to arsenic-containing substance
- xenobiotic metabolic process
- L-ascorbic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- glutathione dehydrogenase (ascorbate) activity
- identical protein binding
- protein binding
- oxidoreductase activity
- glutathione transferase activity
- methylarsonate reductase activity