TRPC7 Gene Summary [Human]
Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within calcium ion transport. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRPC7 |
| Official Name | transient receptor potential cation channel subfamily C member 7 [Source:HGNC Symbol;Acc:HGNC:20754] |
| Ensembl ID | ENSG00000069018 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel subfamily C member 7 |
| Synonyms | transient receptor potential cation channel subfamily C member 7, transient receptor potential cation channel, subfamily C, member 7, TRP7, Trrp8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRPC7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- Ion transport protein
- calcium channel
- Ankyrin repeats (3 copies)
- Transient receptor ion channel II
- transient-receptor-potential calcium channel protein
- protein binding
- ion channel
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- Polycystin cation channel
- cation channel
Pathways
Biological processes and signaling networks where the TRPC7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- cellular membrane
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRPC7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytosolic calcium ion homeostasis
- calcium ion transmembrane transport
- single fertilization
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- perinuclear region of cytoplasm
- cation channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- store-operated calcium channel activity
- protein binding
- calcium channel activity
- inositol 1,4,5 trisphosphate binding