CDHR2 Gene Summary [Human]
This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | CDHR2 |
| Official Name | cadherin related family member 2 [Source:HGNC Symbol;Acc:HGNC:18231] |
| Ensembl ID | ENSG00000074276 |
| Bio databases IDs | |
| Aliases | cadherin related family member 2, protocadherin LKC |
| Synonyms | cadherin-related family member 2, Gm624, PCDH24, PCLCK, PC-LKC, RGD1560576 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDHR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- ectodomain
- cell adhesion molecule binding
- Cadherin repeat-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- microvilli tips
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDHR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- negative regulation of cell growth involved in contact inhibition
- cell-cell adhesion mediated by cadherin
- regulation of microvillus length
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- anchoring junction
- brush border membrane
- extracellular vesicular exosome
- brush border
- microvillus
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- cell adhesion molecule binding