MAST2 Gene Summary [Human]
Enables phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | MAST2 |
| Official Name | microtubule associated serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:19035] |
| Ensembl ID | ENSG00000086015 |
| Bio databases IDs | |
| Aliases | microtubule associated serine/threonine kinase 2 |
| Synonyms | MAST205, Mast2 predicted, microtubule associated serine/threonine kinase 2, MTSSK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAST2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- canonical PDZ domain
- protein binding
- PDZ domain
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- microtubule binding
- Protein Kinases, catalytic domain
- Domain of unknown function (DUF1908)
- Tyrosine kinase, catalytic domain
- protein transduction domain
- phosphatase binding
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the MAST2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- metabolic syndrome X
- sensorineural hearing loss
- esophageal carcinoma
- esophageal carcinoma formation
- breast carcinoma
- prostatic carcinoma
- prostate cancer
- hearing loss
role in cell
- growth
- phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cellular membrane
- neuromuscular junctions
- sarcolemma
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAST2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- spermatid differentiation
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
- regulation of interleukin-12 production
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- microtubule binding