TXK
TXK Gene Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TXK |
| Official Name | TXK tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12434] |
| Ensembl ID | ENSG00000074966 |
| Bio databases IDs | |
| Aliases | TXK tyrosine kinase |
| Synonyms | A130089B16RIK,BTKL,PSCTK5,PTK4,PTK-RL-18,RLK,TKL,TXK tyrosine kinase |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- proline rich domain
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the TXK gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ERBB3
- RBAK
- ZNF792
- STAP2
- PRN694
- GRB2
- EGFR
- SH2D2A
- ERBB2
- DUSP6
disease
- multiple sclerosis
- latent tuberculosis
- atopic dermatitis
- septic shock
- infection by parasite
regulated by
- CXCL12
- SRC (family)
- IL2RG
- STAT6
- BHLHE40
- TCR (complex)
- IL4
- FYN
- GATA2
- IL18
regulates
- ERK1/2
- DNA endogenous promoter
- p38 MAPK
- IL4
- IFNG
- TNF
- PLCG1
- Ca2+
- LCP2
- ITGB2
role in cell
- expression in
- apoptosis
- number
- proliferation
- quantity
- migration
- positive selection
- differentiation
- conjugation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- vesicles
- cytosol
- nucleoplasm
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TXK gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of interferon-gamma production
- regulation of gene expression
- protein autophosphorylation
- adaptive immune response
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- positive regulation of cytokine production
- positive regulation of interferon-gamma-mediated signaling pathway
- T cell receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity