CDC14B Gene Summary [Human]
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CDC14B |
| Official Name | cell division cycle 14B [Source:HGNC Symbol;Acc:HGNC:1719] |
| Ensembl ID | ENSG00000081377 |
| Bio databases IDs | |
| Aliases | cell division cycle 14B |
| Synonyms | 2810432N10Rik, A530086E13RIK, Cdc14B1, Cdc14B2, CDC14B3, CDC14 cell division cycle 14B, cell division cycle 14B, hCDC14B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC14B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein-tyrosine-phoshatase
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- PTP_DSP_cys
- Dual specificity protein phosphatase, N-terminal half
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the CDC14B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- cataract disease
- insomnia
- premature aging
- kyphosis
role in cell
- expression in
- activation in
- degradation in
- growth
- G2/M phase
- stabilization in
- neural cell differentiation
- senescence
- damage in
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC14B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- cilium morphogenesis
- regulation of exit from mitosis
- protein dephosphorylation
- microtubule cytoskeleton organization
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitotic spindle
- cytoplasm
- spindle pole
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- myosin phosphatase activity