TAF1D Gene Summary [Human]
TAF1D is a member of the SL1 complex, which includes TBP (MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C (MIM 604905), and plays a role in RNA polymerase I transcription (Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed 17318177]).[supplied by OMIM, Jun 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TAF1D |
| Official Name | TATA-box binding protein associated factor, RNA polymerase I subunit D [Source:HGNC Symbol;Acc:HGNC:28759] |
| Ensembl ID | ENSG00000166012 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor, RNA polymerase I subunit D |
| Synonyms | 2810003M17Rik, 4930553M18Rik, 5930426I11Rik, JOSD3, MGC5306, RAFI41, RGD1309627, TAFI41, TAF(I)41, TATA-box binding protein associated factor, RNA polymerase I, D, TATA-box binding protein associated factor, RNA polymerase I subunit D |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF1D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TATA box-binding protein-associated factor 1D
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the TAF1D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- neoplasia
- breast cancer
role in cell
- expression in
- proliferation
- growth
- cell viability
- colony formation
- cell cycle progression
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- nucleoli
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF1D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- RNA polymerase transcription factor SL1 complex
- mitotic spindle
- centriolar satellite
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding