PREP Gene Summary [Human]
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PREP |
| Official Name | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] |
| Ensembl ID | ENSG00000085377 |
| Bio databases IDs | |
| Aliases | prolyl endopeptidase, prolyl oligopeptidase |
| Synonyms | D10Wsu136e, PE, PEP, Pop, POST-PROLYL ENDOPEPTIDASE, prolyl endopeptidase, Prolyl Oligopeptidase, rPop |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PREP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- peptide binding
- endopeptidase
- serine endopeptidase
- serine-type peptidase
- peptidase
- Prolyl oligopeptidase, N-terminal beta-propeller domain
- metallocarboxypeptidase
- protein binding
- prolyl oligopeptidase
Pathways
Biological processes and signaling networks where the PREP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- rheumatoid arthritis
- natural killer cell neoplasm
- natural killer cell neoplasia
- androgenic alopecia
- pervasive developmental disorder
- behavioral deficit
- streptozotocin-induced diabetic nephropathy
- impaired glucose tolerance
role in cell
- transmembrane potential
- activation in
- cell viability
- survival
- growth
- degradation in
- differentiation
- quantity
- inactivation in
- serine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PREP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- oligopeptidase activity
- serine-type endopeptidase activity
- serine-type peptidase activity