RRN3 Gene Summary [Human]
Enables RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter. Predicted to act upstream of or within several processes, including DNA-templated transcription, initiation; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of transcription, DNA-templated. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RRN3 |
| Official Name | RRN3 homolog, RNA polymerase I transcription factor [Source:HGNC Symbol;Acc:HGNC:30346] |
| Ensembl ID | ENSG00000085721 |
| Bio databases IDs | |
| Aliases | RRN3 homolog, RNA polymerase I transcription factor, transcription initiation factor IA |
| Synonyms | A-270G1.2, AL023001, E130302O19Rik, LOC100910121, RGD1305001, RRN3 homolog, RNA polymerase I transcription factor, RRN3 RNA polymerase I transcription factor homolog (yeast), TIF-1A, TIF-IA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase I specific transcription initiation factor RRN3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- growth failure
- schizophrenia
regulates
- DNA promoter
- MTOR
- dopamine
- DNA endogenous promoter
- RNA polymerase I
- 8-oxo-dGMP
- neuroketal
role in cell
- survival
- proliferation
- cell death
- apoptosis
- loss
- development
- organization
- biogenesis
- dysfunction
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- RNA polymerase I transcriptional preinitiation complex assembly
- regulation of transcription initiation, DNA-dependent
- transcription initiation from RNA polymerase I promoter
- in utero embryonic development
- nucleolus organization
- positive regulation of transcription, DNA-dependent
- signal transduction by p53 class mediator resulting in induction of apoptosis
- homeostasis of number of cells
- ribosome biogenesis
- cytoplasm organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase I CORE element sequence-specific DNA binding
- RNA polymerase I core binding
- core RNA polymerase I binding transcription factor activity