NOP14 Gene Summary [Human]
This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Details
| Type | Processed Transcript |
| Official Symbol | NOP14 |
| Official Name | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] |
| Ensembl ID | ENSG00000087269 |
| Bio databases IDs | |
| Aliases | NOP14 nucleolar protein, NOP14 homolog (S. cerevisiae) |
| Synonyms | 2610033H07Rik, C4orf9, NOL14, NOP14 nucleolar protein, RES4-25, RGD1305605, UTP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOP14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nop14-like family
- enzyme binding
- snoRNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOP14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- maturation of SSU-rRNA
- ribosomal small subunit biogenesis
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- membrane
- Noc4p-Nop14p complex
- nucleolus
- 90S preribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- snoRNA binding
- RNA binding
- enzyme binding