PLAAT4 Gene Summary [Human]
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PLAAT4 |
| Official Name | phospholipase A and acyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:9869] |
| Ensembl ID | ENSG00000133321 |
| Bio databases IDs | |
| Aliases | phospholipase A and acyltransferase 4, phospholipase A/acyltransferase‐4, Retinoid-inducible gene 1 |
| Synonyms | HRASLS4, HRSL4, phospholipase A and acyltransferase 4, PLA1/2-3, RARRES3, RIG1, TIG3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLAAT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA helicase domain
- phospholipase A1
- N-acyltransferase
- NlpC/P60 family
- enzyme
- protein binding
- DExD/H-box helicase domain
- transferase, transferring acyl groups
- phospholipase A2
- helicase domain
- transcription repression domain
- IP3-binding suppressor domain
- membrane attachment signal
- RNA-binding domain
Pathways
Biological processes and signaling networks where the PLAAT4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- skin basal cell carcinoma
- basal cell skin cancer
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- skin cancer
- pervasive developmental disorder
- infection by vesicular stomatitis virus
- infection by Toxoplasma gondii
role in cell
- expression in
- growth
- cell viability
- recruitment in
- quantity
- phosphorylation in
- activation in
- proliferation
- survival
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular compartment
- intracellular space
- cellular membrane
- cytoplasmic aggregates
- cytosol
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLAAT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- N-acylphosphatidylethanolamine metabolic process
- phosphatidylethanolamine acyl-chain remodeling
- negative regulation of cell proliferation
- lipid catabolic process
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity
- transferase activity, transferring acyl groups
- protein binding
- phosphatidylserine 1-acylhydrolase activity
- phosphatidylcholine 1-acylhydrolase activity
- N-acyltransferase activity