IRAK2 Gene Summary [Human]
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IRAK2 |
| Official Name | interleukin 1 receptor associated kinase 2 [Source:HGNC Symbol;Acc:HGNC:6113] |
| Ensembl ID | ENSG00000134070 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor associated kinase 2 |
| Synonyms | 6330415L08Rik, interleukin-1 receptor-associated kinase 2, INTERLEUKIN-1 receptor-ASSOCIATED KINASE-LIKE 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRAK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- protein serine/threonine kinase
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding activity, bridging
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Death Domain Superfamily of protein-protein interaction domains
- protein heterodimerization
Pathways
Biological processes and signaling networks where the IRAK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polycythemia vera
- insulin resistance
- weight gain
- endotoxin shock response
- septic shock
- primary myelofibrosis
- essential thrombocythemia
- neonatal late-onset sepsis
role in cell
- expression in
- apoptosis
- cell death
- phosphorylation in
- production in
- activation in
- transactivation in
- damage
- oxidation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRAK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Toll signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- toll-like receptor 4 signaling pathway
- I-kappaB kinase/NF-kappaB cascade
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- inflammatory response
- MyD88-dependent toll-like receptor signaling pathway
- cellular response to lipopolysaccharide
- response to interleukin-1
- lipopolysaccharide-mediated signaling pathway
- regulation of cytokine-mediated signaling pathway
- interleukin-1-mediated signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- protein binding
- signaling adaptor activity
- protein heterodimerization activity
- protein kinase activity
- binding, bridging