ZC3HC1 Gene Summary [Human]
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | ZC3HC1 |
| Official Name | zinc finger C3HC-type containing 1 [Source:HGNC Symbol;Acc:HGNC:29913] |
| Ensembl ID | ENSG00000091732 |
| Bio databases IDs | |
| Aliases | zinc finger C3HC-type containing 1, nuclear interaction partner of ALK |
| Synonyms | 1110054L24Rik, HSPC216, NIPA, RGD1561099, zinc finger, C3HC type 1, zinc finger C3HC-type containing 1, zinc finger, C3HC-type containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZC3HC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C3HC zinc finger-like
- protein kinase binding
- protein binding
- Rsm1-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- myocardial infarction
- metabolic syndrome X
- impotence
- cardiovascular disorder
- essential hypertension
- angina pectoris
- hypertension
- heart disease
- azoospermia
role in cell
- apoptosis
- accumulation in
- mitosis
- meiosis
- abnormal morphology
- number
- mitotic index
- excision repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZC3HC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- protein binding