RANBP1 Gene Summary [Human]

This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Details

Type
Protein Coding
Official Symbol
RANBP1
Official Name
RAN binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9847]
Ensembl ID
ENSG00000099901
Bio databases IDs NCBI: 5902 Ensembl: ENSG00000099901
Aliases RAN binding protein 1
Synonyms HTF9A, RAN binding protein 1, Ran-Specific GTPase-Activating
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RANBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • nuclear export signal
  • GDP-dissociation inhibitor
  • enzyme binding
  • protein binding
  • Pleckstrin homology-like domain
  • Ran binding domain

Pathways

Biological processes and signaling networks where the RANBP1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • breast cancer
  • colorectal cancer
  • psoriasis
  • neoplasia
  • metastasis
  • organismal death
  • lymphoma
  • lymphomagenesis
  • growth failure
  • Huntington disease
regulated by
regulates
role in cell
  • proliferation
  • apoptosis
  • phosphorylation in
  • expression in
  • invasion by
  • growth
  • accumulation in
  • formation
  • development
  • response by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • centrosome
  • cytosol
  • nuclear envelope
  • fibrils
  • cellular protrusions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RANBP1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • nucleocytoplasmic transport
  • signal transduction
  • positive regulation of mitotic centrosome separation

Cellular Component

Where in the cell the gene product is active
  • nuclear envelope
  • nucleus
  • centrosome
  • cytoplasm
  • cytosol
  • nuclear pore

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • GDP-dissociation inhibitor activity
  • cadherin binding
  • GTPase activator activity
  • small GTPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.