DAAM1

DAAM1 Gene Summary

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

Details

Type
Retained Intron
Official Symbol
DAAM1
Official Name
dishevelled associated activator of morphogenesis 1 [Source:HGNC Symbol;Acc:HGNC:18142]
Ensembl ID
ENSG00000100592
Bio databases IDs NCBI: 23002 Ensembl: ENSG00000100592
Aliases dishevelled associated activator of morphogenesis 1
Synonyms
Daam1 predicted,dishevelled associated activator of morphogenesis 1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Formin Homology 2 Domain
  • Diaphanous FH3 Domain
  • protein binding
  • identical protein binding
  • Diaphanous GTPase-binding Domain

Pathways

Biological processes and signaling networks where the DAAM1 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • UBE3A
  • DAAM1
  • RHOQ
  • CCNF
  • RAC2
  • PRPF40A
  • SERBP1
  • RHOD
  • DLGAP5
  • FNBP1
disease
  • non-insulin-dependent diabetes mellitus
  • major depression
  • oral squamous cell carcinoma
  • squamous cell cancer of the oral cavity
  • diabetic nephropathy
  • organismal death
  • essential thrombocythemia
regulated by
  • ERG
  • SRC
  • ERBB2
  • HNF4A
  • TGFB1
  • EZH2
  • PTEN
  • HNF4G
  • COL4
  • WNT3A
regulates
  • actin
  • profilin
  • DVL2
  • RHOA
  • WNT
  • DAAM1
role in cell
  • migration
  • proliferation
  • activation in
  • expression in
  • invasion by
  • number
  • formation
  • assembly
  • polarization
  • haptotaxis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • detergent resistant lipid raft fraction
  • motile cilia
  • glutaminergic synapse
  • presynaptic regions
  • perinuclear region
  • Plasma Membrane
  • basal bodies
  • cytosol
  • synapse
  • Z line
  • actin stress fibers
  • filopodia
  • filopodial shafts
  • lamellipodia

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the DAAM1 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • Wnt receptor signaling pathway, planar cell polarity pathway
  • actin cytoskeleton organization

CELLULAR COMPONENT

Where in the cell the gene product is active
  • motile cilium
  • perinuclear region of cytoplasm
  • cilium basal body
  • membrane
  • stress fiber
  • cytosol
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • identical protein binding
  • protein binding
  • actin binding
  • small GTPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.