Daam1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in Wnt signaling pathway and presynaptic actin cytoskeleton organization. Located in perinuclear region of cytoplasm and stress fiber. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and gut. Used to study intrinsic cardiomyopathy. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Daam1 |
| Official Name | dishevelled associated activator of morphogenesis 1 [Source:MGI Symbol;Acc:MGI:1914596] |
| Ensembl ID | ENSMUSG00000034574 |
| Bio databases IDs | |
| Aliases | dishevelled associated activator of morphogenesis 1 |
| Synonyms | Daam1 predicted, dishevelled associated activator of morphogenesis 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Daam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- Diaphanous FH3 Domain
- protein binding
- identical protein binding
- Diaphanous GTPase-binding Domain
Pathways
Biological processes and signaling networks where the Daam1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- major depression
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- diabetic nephropathy
- organismal death
- essential thrombocythemia
role in cell
- migration
- proliferation
- activation in
- expression in
- invasion by
- number
- formation
- assembly
- polarization
- haptotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- motile cilia
- glutaminergic synapse
- presynaptic regions
- perinuclear region
- Plasma Membrane
- basal bodies
- cytosol
- synapse
- Z line
- actin stress fibers
- filopodia
- filopodial shafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Daam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt receptor signaling pathway, planar cell polarity pathway
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- motile cilium
- perinuclear region of cytoplasm
- cilium basal body
- membrane
- stress fiber
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- actin binding
- small GTPase binding