PCIF1 Gene Summary [Human]
Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA methylation; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PCIF1 |
| Official Name | phosphorylated CTD interacting factor 1 [Source:HGNC Symbol;Acc:HGNC:16200] |
| Ensembl ID | ENSG00000100982 |
| Bio databases IDs | |
| Aliases | phosphorylated CTD interacting factor 1, protein phosphatase 1, regulatory subunit 121, cap-specific adenosine methyltransferase' |
| Synonyms | 2310022K11Rik, 4930445K14Rik, C20orf67, CAPAM, DKFZP434e1723, F730014I05Rik, hCAPAM, hPCIF1, MT-A70, phosphorylated CTD interacting factor 1, PPP1R121, RGD1310800 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCIF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphorylated CTD interacting factor 1 WW domain
- Domain with 2 conserved Trp (W) residues
- binding protein
- WW
- enzyme binding
- enzyme
- mRNA (2'-O-methyladenosine-N6-)-methyltransferase
- protein binding
- phosphoprotein amino acid binding
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- pancreatic cancer
- glioblastoma
- glioblastoma cancer
- abdominal aortic aneurysm
- colorectal cancer
regulated by
- dexamethasone
- troglitazone
- VPR
- rifampin
- EFNA1
- ritonavir
role in cell
- expression in
- cell viability
- migration
- colony formation
- replication in
- invasion by
- sphere formation
- cellular infiltration by
- modification in
- N6-methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- cytoplasmic bridges
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCIF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- positive regulation of translation
- mRNA processing
- negative regulation of translation
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- intercellular bridge
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity