PARP16 Gene Summary [Human]
Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of protein serine/threonine kinase activity; and protein ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PARP16 |
| Official Name | poly(ADP-ribose) polymerase family member 16 [Source:HGNC Symbol;Acc:HGNC:26040] |
| Ensembl ID | ENSG00000138617 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 16 |
| Synonyms | ARTD15, C15orf30, C79952, LRRGT00109, pART15, poly (ADP-ribose) polymerase family, member 16, poly(ADP-ribose) polymerase family member 16, RGD1306243 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARP16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- kinase binding
- pentosyltransferase
- carboxy-terminal luminal tail domain
- NAD ADP-ribosyltransferase
- Poly(ADP-ribose) polymerase catalytic domain
- enzyme
- protein binding
- ARTD15 N-terminal domain
Pathways
Biological processes and signaling networks where the PARP16 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- neurological disorder
regulated by
- NAD+
- filgrastim
- dexamethasone
- brefeldin A
- thapsigargin
- tunicamycin
role in cell
- cell death
- expression in
- growth
- activation in
- protection
- ADP ribosylation in
- endoplasmic reticulum stress response
- mono-ADP-ribosylation in
- endoplasmic reticulum stress response in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum tubules
- Endoplasmic Reticulum
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARP16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- endoplasmic reticulum unfolded protein response
- NAD biosynthesis via nicotinamide riboside salvage pathway
- protein auto-ADP-ribosylation
- negative regulation of cytoplasmic translation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- endoplasmic reticulum tubular network
- membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- protein serine/threonine kinase activator activity
- kinase binding
- NAD+ ADP-ribosyltransferase activity