ASIP Gene Summary [Human]
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ASIP |
| Official Name | agouti signaling protein [Source:HGNC Symbol;Acc:HGNC:745] |
| Ensembl ID | ENSG00000101440 |
| Bio databases IDs | |
| Aliases | agouti signaling protein, nonagouti homolog (mouse) |
| Synonyms | A, agouti, agouti signaling protein, AGSW, AGTI, AGTIL, As, ASP, nonagouti, SHEP9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reverse transcriptase thumb domain
- Zinc knuckle
- RNAse H
- Retroviral GAG p10 protein
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- Gag protein p24 C-terminal domain
- Reverse transcriptase (RNA-dependent DNA polymerase)
- zinc finger
- Integrase zinc binding domain
- Integrase core domain
- ENV polyprotein (coat polyprotein)
- basic domain
- GAG-polyprotein viral zinc-finger
- Integrase DNA binding domain
- Agouti protein
- Ebola_HIV-1-like_HR1-HR2
- gag protein p24 N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperglycemia
- obesity
- hyperinsulinism
- non-insulin-dependent diabetes mellitus
- acanthosis
- non-melanoma skin cancer
- hyperplasia
- adult-onset obesity
- hyperphagia
role in cell
- expression in
- formation
- proliferation
- binding in
- induction
- degradation in
- accumulation in
- activation
- organization
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ASIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of melanin biosynthetic process
- melanin biosynthetic process
- generation of precursor metabolites and energy
- melanosome organization
- signal transduction
- cell-cell signaling
- adult feeding behavior
- melanosome transport
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- melanocortin receptor binding
- neuropeptide hormone activity
- type 3 melanocortin receptor binding
- type 4 melanocortin receptor binding
- receptor binding