a Gene Summary [Mouse]
Enables type 3 melanocortin receptor binding activity and type 4 melanocortin receptor binding activity. Involved in melanin biosynthetic process and positive regulation of melanin biosynthetic process. Acts upstream of or within several processes, including adult feeding behavior; melanosome organization; and melanosome transport. Predicted to be active in extracellular space. Is expressed in forelimb epithelium; hair bulb; hindlimb epithelium; and skin. Used to study abdominal obesity-metabolic syndrome 1; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in pigmentation disease. Orthologous to human ASIP (agouti signaling protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | a |
| Official Name | nonagouti [Source:MGI Symbol;Acc:MGI:87853] |
| Ensembl ID | ENSMUSG00000027596 |
| Bio databases IDs | |
| Aliases | nonagouti |
| Synonyms | A, agouti, agouti signaling protein, AGSW, AGTI, AGTIL, As, ASP, nonagouti, SHEP9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reverse transcriptase thumb domain
- Zinc knuckle
- RNAse H
- Retroviral GAG p10 protein
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- Gag protein p24 C-terminal domain
- Reverse transcriptase (RNA-dependent DNA polymerase)
- zinc finger
- Integrase zinc binding domain
- Integrase core domain
- ENV polyprotein (coat polyprotein)
- basic domain
- GAG-polyprotein viral zinc-finger
- Integrase DNA binding domain
- Agouti protein
- Ebola_HIV-1-like_HR1-HR2
- gag protein p24 N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperglycemia
- obesity
- hyperinsulinism
- non-insulin-dependent diabetes mellitus
- acanthosis
- non-melanoma skin cancer
- hyperplasia
- adult-onset obesity
- hyperphagia
role in cell
- expression in
- formation
- proliferation
- binding in
- induction
- degradation in
- accumulation in
- activation
- organization
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of melanin biosynthetic process
- melanin biosynthetic process
- generation of precursor metabolites and energy
- melanosome organization
- signal transduction
- cell-cell signaling
- adult feeding behavior
- melanosome transport
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- melanocortin receptor binding
- neuropeptide hormone activity
- type 3 melanocortin receptor binding
- type 4 melanocortin receptor binding
- receptor binding