SNCAIP Gene Summary [Human]
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | SNCAIP |
| Official Name | synuclein alpha interacting protein [Source:HGNC Symbol;Acc:HGNC:11139] |
| Ensembl ID | ENSG00000064692 |
| Bio databases IDs | |
| Aliases | synuclein alpha interacting protein, synphilin |
| Synonyms | 2810407O15Rik, 4933427B05Rik, Sph1, Synphilin-1, synuclein alpha interacting protein, synuclein, alpha interacting protein, synuclein, alpha interacting protein (synphilin), synuclein α interacting protein, synuclein, α interacting protein, synuclein, α interacting protein (synphilin), SYPH1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNCAIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- ankyrin binding domain
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- coiled-coil domain
- protein binding
- Synphilin-1 alpha-Synuclein-binding domain
- identical protein binding
- ankyrin repeats
Pathways
Biological processes and signaling networks where the SNCAIP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- epithelial cancer
- diabetic nephropathy
- liver cancer
- squamous cell cancer
- oligodendroglioma
- glioma formation
- renal cell carcinoma
- renal cell cancer
- melanoma
role in cell
- cell viability
- cell death
- formation
- formation in
- assembly
- degradation in
- aggregation in
- ubiquitination in
- autoubiquitination in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytosol
- nucleoplasm
- synaptic vesicles
- synaptosomes
- membrane processes
- perikaryon
- presynaptic terminals
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNCAIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- dopamine metabolic process
- cell death
- regulation of inclusion body assembly
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- cytoplasm
- synaptic vesicle
- cytosol
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- ubiquitin protein ligase binding
- protein binding