EIF3J Gene Summary [Human]

This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

Details

Type
Protein Coding
Official Symbol
EIF3J
Official Name
eukaryotic translation initiation factor 3 subunit J [Source:HGNC Symbol;Acc:HGNC:3270]
Ensembl ID
ENSG00000104131
Bio databases IDs NCBI: 8669 Ensembl: ENSG00000104131
Aliases eukaryotic translation initiation factor 3 subunit J
Synonyms 1810016I04Rik, 2700079K05Rik, eIF3-alpha, eIF-3-alpha-A, eIF-3-alpha-B, Eif3j1, Eif3j-2, eIF3j-A, eIF3j-B, eIF3-p35, EIF3S1, Eif3s1 (predicted), eIF3-α, eIF-3-α-A, eIF-3-α-B, eukaryotic translation initiation factor 3 subunit J, eukaryotic translation initiation factor 3, subunit J, eukaryotic translation initiation factor 3, subunit J1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF3J often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Translation initiation factor eIF3 subunit
  • protein binding
  • identical protein binding
  • translation regulator

Pathways

Biological processes and signaling networks where the EIF3J gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • androgenic alopecia
  • aortic valve calcification
regulated by
  • beta-estradiol
  • EGFR
  • EIF1
  • EIF3
  • tetradecanoylphorbol acetate
  • T lymphocytes
  • sirolimus
  • mir-27 (includes others)
  • EDN1
  • CYP1B1
regulates
role in cell
  • expression in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human EIF3J gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • formation of translation initiation complex
  • translational initiation

Cellular Component

Where in the cell the gene product is active
  • eukaryotic 43S preinitiation complex
  • cytosol
  • eukaryotic 48S preinitiation complex
  • eukaryotic translation initiation factor 3 complex

Molecular Function

What the gene product does at the molecular level
  • translation initiation factor activity
  • identical protein binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.