EIF1 Gene Summary [Human]
Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | EIF1 |
| Official Name | eukaryotic translation initiation factor 1 [Source:HGNC Symbol;Acc:HGNC:3249] |
| Ensembl ID | ENSG00000173812 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 1 |
| Synonyms | A121, EIF1A, eukaryotic translation initiation factor 1, ISO1, SUI1, SUI1-RS1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- Translation initiation factor SUI1
- translation initiation factor
- protein binding
- translation regulator
- Eukaryotic initiation factor 1 and related proteins
- ribosomal small subunit binding
Pathways
Biological processes and signaling networks where the EIF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- tumorigenesis
- COVID-19
- endometriosis
- systemic juvenile idiopathic arthritis
- atopic dermatitis
role in cell
- growth
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- multi-eIF complex
- nucleus
- cytoplasm
- eukaryotic 43S preinitiation complex
- eukaryotic 48S preinitiation complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- RNA binding
- ribosomal small subunit binding
- translation factor activity, nucleic acid binding