TRMT1L Gene Summary [Human]

This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]

Details

Type
Protein Coding
Official Symbol
TRMT1L
Official Name
tRNA methyltransferase 1 like [Source:HGNC Symbol;Acc:HGNC:16782]
Ensembl ID
ENSG00000121486
Bio databases IDs NCBI: 81627 Ensembl: ENSG00000121486
Aliases tRNA methyltransferase 1 like, TRM1-like
Synonyms 1190005F20Rik, bG120K12.3, C1orf25, MST070, MSTP070, RGD1307890, TRM1L, Trm1-like, tRNA methyltransferase 1L, tRNA methyltransferase 1-like
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRMT1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • N2,N2-dimethylguanosine tRNA methyltransferase
  • tRNA(guanine-26,N2-N2) methyltransferase
  • enzyme
  • protein binding
  • AdoMet_MTases

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-small cell lung cancer
regulated by
  • aphidicolin
role in cell
  • processing in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TRMT1L gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • nucleus

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • protein binding
  • metal ion binding
  • tRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.