MAP4K1 Gene Summary [Human]
Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | MAP4K1 |
| Official Name | mitogen-activated protein kinase kinase kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6863] |
| Ensembl ID | ENSG00000104814 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase kinase 1, hematopoietic progenitor kinase 1 |
| Synonyms | haematopoietic progenitor kinase 1, HPK1, M4K1, mHPK1, mitogen-activated protein kinase kinase kinase kinase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP4K1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- regulatory domain
- Protein tyrosine and serine/threonine kinase
- CNH domain
- ATP binding
- protein binding
- Protein kinase domain
- polyproline motif
- proline rich domain
- Sh3 domain binding motif
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- MAP kinase kinase kinase kinase
- Tyrosine kinase, catalytic domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the MAP4K1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- neoplasia
- non-Hodgkin lymphoma
- non-Hodgkin disease
- COVID-19
- malignant neoplasm
- organismal death
- glioblastoma
- glioblastoma cancer
- glioma formation
role in cell
- expression in
- phosphorylation in
- apoptosis
- proliferation
- activation in
- differentiation
- binding in
- ubiquitination in
- adhesion
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP4K1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- protein autophosphorylation
- JNK cascade
- positive regulation of MAPK cascade
- peptidyl-serine phosphorylation
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- MAP kinase kinase kinase kinase activity