FCER2 Gene Summary [Human]
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | FCER2 |
| Official Name | Fc fragment of IgE receptor II [Source:HGNC Symbol;Acc:HGNC:3612] |
| Ensembl ID | ENSG00000104921 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgE receptor II, Fc epsilon receptor II, Fc epsilon RII, C-type lectin domain family 4 member J |
| Synonyms | BLAST-2, CD23, Cd23a, CD23B, CLEC4J, epsilon-BCR, FCE2, Fc epsilon receptor II, FCER2A, FCErII, Fc receptor, IgE, low affinity II, alpha polypeptide, Fc receptor, IgE, low affinity II, α polypeptide, Fc ε receptor II, FC ε RII, IGEBF, IGE receptor, Ly-42, sCD23, secreted CD23, ε-BCR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCER2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- SynN
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protease binding
- ectodomain
- low affinity IgE receptor
- integrin binding
- Lectin C-type domain
- protein binding
- transmembrane receptor
- IgE binding
Pathways
Biological processes and signaling networks where the FCER2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- follicular B-cell or T-cell lymphoma
- chronic lymphocytic leukemia / small lymphocytic lymphoma
- insulin-dependent diabetes mellitus
- gastric marginal zone B cell lymphoma
- gastric cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- non-Hodgkin disease
- acute myeloid leukemia
role in cell
- apoptosis
- proliferation
- growth
- recruitment
- binding
- quantity
- activation
- killing
- function
- deposition by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCER2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- interspecies interaction between organisms
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric-oxide synthase activity
- Fc-epsilon receptor signaling pathway
- positive regulation of humoral immune response mediated by circulating immunoglobulin
- B cell antigen processing and presentation
- positive regulation of killing of cells of other organism
- macrophage activation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- low affinity IgE receptor activity
- protein binding
- metal ion binding
- protease binding
- integrin binding
- IgE binding
- carbohydrate binding