AKAP8 Gene Summary [Human]
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | AKAP8 |
| Official Name | A-kinase anchoring protein 8 [Source:HGNC Symbol;Acc:HGNC:378] |
| Ensembl ID | ENSG00000105127 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 8, A-kinase anchor protein, 95kDa |
| Synonyms | 1200016A02Rik, AKAP-95, A-kinase anchoring protein 8, A kinase anchor protein 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKAP8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- zinc ion binding
- double-stranded DNA binding
- NF-kappaB binding
- A-kinase anchoring protein 95 (AKAP95)
- histone deacetylase binding
- chromatin binding
- R2 binding domain
- protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the AKAP8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cleft palate syndrome
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- expression in
- response
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- nuclear matrix
- pronucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKAP8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- mitotic chromosome condensation
- signal transduction
- innate immune response
- protein transport
- cellular response to prostaglandin E stimulus
- negative regulation of tumor necrosis factor production
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- cytoplasm
- membrane
- nuclear matrix
- female pronucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- zinc ion binding
- RNA binding
- protein binding
- histone deacetylase binding
- protein kinase A regulatory subunit binding
- double-stranded DNA binding