NR2F6 Gene Summary [Human]
Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NR2F6 |
| Official Name | nuclear receptor subfamily 2 group F member 6 [Source:HGNC Symbol;Acc:HGNC:7977] |
| Ensembl ID | ENSG00000160113 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 2 group F member 6 |
| Synonyms | COUP-TF3, EAR-2, ERBAL2, nuclear receptor subfamily 2 group F member 6, nuclear receptor subfamily 2, group F, member 6, V-ERBA PROTO-ONCOGENE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR2F6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- nucleic acid binding
- ligand-binding domain
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- protein binding
- Ligand-binding domain of nuclear hormone receptor
- sequence-specific DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the NR2F6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- glioma formation
- luminal A breast carcinoma
- luminal A breast cancer
- touch abnormality
role in cell
- expression in
- growth
- cellular infiltration by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR2F6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- entrainment of circadian clock by photoperiod
- anatomical structure development
- cell differentiation
- neuron development
- detection of temperature stimulus involved in sensory perception of pain
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity