DDX58 Gene Summary [Human]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | DDX58 |
| Official Name | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] |
| Ensembl ID | ENSG00000107201 |
| Bio databases IDs | |
| Aliases | DExD/H-box helicase 58, RNA helicase RIG-I, retinoic acid inducible gene I |
| Synonyms | 6430573D20Rik, C330021E21, DDX58, RIG1, RLR-1, RNA HELICASE, RNA sensor RIG-1, RNA sensor RIG-I, SGMRT2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDX58 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- C-terminal regulatory domain
- ATP-binding domain
- enzyme
- identical protein binding
- ATPase
- Helicase conserved C-terminal domain
- RNA helicase
- helicase domain
- Caspase recruitment domain
- CARD-like domain
- zinc ion binding
- ATPase domain
- double-stranded RNA binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- RIG-I receptor C-terminal domain
- DEAD-like helicases superfamily
- C-terminal domain of RIG-I
- P-loop containing Nucleoside Triphosphate Hydrolases
- ubiquitin protein ligase binding
- RNA helicase domain
- signaling receptor activity
- DEAD/DEAH box helicase
- linker domain
- protein binding
- DExD/H-box helicase domain
- single-stranded RNA binding
- GTP binding
- transcription repression domain
- RLR_C_like
- double-stranded DNA binding
- helicase_insert_domain
- Death Domain Superfamily of protein-protein interaction domains
- RNA-binding domain
Pathways
Biological processes and signaling networks where the DDX58 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- neoplasia
- infection
- Singleton-Merten syndrome type 2
- glioma
- glioma formation
- breast carcinoma
- metastasis
- psoriasis
- idiopathic inflammatory myopathy
role in cell
- expression in
- proliferation
- apoptosis
- production in
- phosphorylation in
- activation in
- cell death
- activation
- recruitment
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear body
- cell surface
- intracellular space
- actin cytoskeleton
- Plasma Membrane
- vesicles
- cytoplasmic particles
- cytosol
- membrane ruffles
- secretory vesicles
- tight junctions
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDX58 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of response to cytokine stimulus
- detection of virus
- positive regulation of defense response to virus by host
- positive regulation of transcription from RNA polymerase II promoter
- response to virus
- cytoplasmic pattern recognition receptor signaling pathway
- positive regulation of interferon-alpha production
- positive regulation of interleukin-8 production
- cellular response to exogenous dsRNA
- positive regulation of granulocyte macrophage colony-stimulating factor production
- positive regulation of myeloid dendritic cell cytokine production
- positive regulation of gene expression
- positive regulation of interferon-beta production
- response to exogenous dsRNA
- innate immune response
- RIG-I signaling pathway
- gene expression
- defense response to virus
- positive regulation of tumor necrosis factor production
- regulation of type III interferon production
- regulation of cell migration
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytoplasm
- actin cytoskeleton
- cytosol
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATPase activity
- ATP binding
- zinc ion binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- RNA helicase activity
- double-stranded RNA binding
- single-stranded RNA binding
- double-stranded DNA binding