PTGER4 Gene Summary [Human]
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PTGER4 |
| Official Name | prostaglandin E receptor 4 [Source:HGNC Symbol;Acc:HGNC:9596] |
| Ensembl ID | ENSG00000171522 |
| Bio databases IDs | |
| Aliases | prostaglandin E receptor 4 |
| Synonyms | EP4, EP4R, prostaglandin E receptor 4, prostaglandin E receptor 4 (subtype EP4), Ptger, Ptgerep4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGER4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin E receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGER4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- macular degeneration
- experimental autoimmune encephalomyelitis
- neoplasia
- cancer
- squamous cell cancer
- epithelial cancer
- weight gain
- arthritis
- congestion
- osteoarthritis
role in cell
- expression in
- proliferation
- differentiation
- apoptosis
- activation in
- function
- production in
- phosphorylation in
- activation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- primary cilia
- nuclear envelope
- nerve ending
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGER4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- positive regulation of inflammatory response
- regulation of stress fiber assembly
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- JNK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to prostaglandin E stimulus
- response to nematode
- bone development
- elevation of cytosolic calcium ion concentration
- response to mechanical stimulus
- ERK1 and ERK2 cascade
- T-helper cell differentiation
- inflammatory response
- cellular response to mechanical stimulus
- immune response
- negative regulation of eosinophil extravasation
- response to lipopolysaccharide
- negative regulation of cytokine production
- regulation of ossification
- positive regulation of cytokine production
- negative regulation of integrin activation
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- prostaglandin E receptor activity