METTL16 Gene Summary [Human]
Enables RNA binding activity and RNA methyltransferase activity. Involved in RNA modification and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | METTL16 |
| Official Name | methyltransferase like 16 [Source:HGNC Symbol;Acc:HGNC:28484] |
| Ensembl ID | ENSG00000127804 |
| Bio databases IDs | |
| Aliases | methyltransferase like 16, methyltransferase 16, N6-methyladenosine, U6 snRNA methyltransferase |
| Synonyms | 2610100D03Rik, 2810013M15RIK, A830095F14RIK, AI846133, methyltransferase 16, N6-methyladenosine, methyltransferase 16, RNA N6-adenosine, METT10D |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA (N6-adenosine)-methyltransferase
- RNA methyltransferase
- U6 snRNA 3' end binding
- enzyme
- AdoMet_MTases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- melanoma cancer
- cancer
- insomnia
- epithelial neoplasia
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
role in cell
- phosphorylation in
- expression in
- proliferation
- migration
- invasion by
- colony formation
- growth
- JQ1 resistance
- translation in
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional regulation of gene expression
- mRNA destabilization
- rRNA base methylation
- regulation of nuclear mRNA splicing, via spliceosome
- mRNA processing
- S-adenosylmethionine biosynthetic process
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- mRNA (N6-adenosine)-methyltransferase activity
- U6 snRNA 3'-end binding
- 23S rRNA (adenine(1618)-N(6))-methyltransferase activity
- RNA stem-loop binding