UNC5B Gene Summary [Human]
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | UNC5B |
| Official Name | unc-5 netrin receptor B [Source:HGNC Symbol;Acc:HGNC:12568] |
| Ensembl ID | ENSG00000107731 |
| Bio databases IDs | |
| Aliases | unc-5 netrin receptor B |
| Synonyms | 6330415E02Rik, A630020F16, D10BWG0792E, p53RDL1, UNC5H2, unc-5 netrin receptor B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UNC5B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- extracellular domain
- thrombospondin-1 motif
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- UPA domain
- ZU5 domain
- Immunoglobulin like
- intracellular domain
- membrane-proximal domain
- Spondin-like TSP1 domain
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
- netrin receptor
Pathways
Biological processes and signaling networks where the UNC5B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- attention deficit hyperactivity disorder
- reperfusion injury
- coronary aneurysm
- allodynia
- osteosarcoma
- osteosarcomagenesis
role in cell
- apoptosis
- migration
- expression in
- growth
- formation
- formation in
- invasion
- cell death
- cellular infiltration by
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UNC5B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- angiogenesis
- apoptotic process
- anterior/posterior axon guidance
- netrin-activated signaling pathway
- positive regulation of protein kinase B signaling cascade
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- netrin receptor activity