ARHGAP21 Gene Summary [Human]
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARHGAP21 |
| Official Name | Rho GTPase activating protein 21 [Source:HGNC Symbol;Acc:HGNC:23725] |
| Ensembl ID | ENSG00000107863 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 21 |
| Synonyms | 5530401C11Rik, ARHGAP10, RHO-GAP10, Rho GTPase activating protein 21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- zDHHC ankyrin repeat binding domain
- ARF domain
- PH domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- uterine neoplasm
- age-related macular degeneration
role in cell
- replication in
- expression in
- migration
- endocytosis by
- cell-cell adhesion
- acetylation in
- organization
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- actin cytoskeleton
- Plasma Membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organelle transport along microtubule
- maintenance of Golgi location
- establishment of Golgi localization
- regulation of small GTPase mediated signal transduction
- signal transduction
- Golgi organization
- Golgi localization
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- anchoring junction
- actin cytoskeleton
- cytosol
- cell junction
- Golgi apparatus
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity