ZMIZ1 Gene Summary [Human]
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | ZMIZ1 |
| Official Name | zinc finger MIZ-type containing 1 [Source:HGNC Symbol;Acc:HGNC:16493] |
| Ensembl ID | ENSG00000108175 |
| Bio databases IDs | |
| Aliases | zinc finger MIZ-type containing 1 |
| Synonyms | E330020C23, Gm10397, I920194n01, LOC102553140, MIZ, NEDDFSA, RAI17, TRAFIP10, ZIMP10, zinc finger MIZ-type containing 1, zinc finger, MIZ-type containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZMIZ1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- transcription co-activator
- Zmiz1 N-terminal tetratricopeptide repeat domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- metabolic syndrome X
- major depression
- schizophrenia
- epithelial cancer
- cancer
- abdominal cancer
- inflammatory bowel disease
- neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies
- multiple sclerosis
role in cell
- growth
- expression in
- differentiation
- activation in
- proliferation
- colony formation by
- transcription in
- senescence in
- transactivation in
- dexamethasone sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZMIZ1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vitellogenesis
- protein sumoylation
- SMAD protein signal transduction
- cellular senescence
- pyramidal neuron migration
- transforming growth factor beta receptor signaling pathway
- artery morphogenesis
- vasculogenesis
- developmental growth
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- regulation of transcription from RNA polymerase II promoter
- heart morphogenesis
- in utero embryonic development
- positive regulation of T cell differentiation
- positive regulation of fibroblast proliferation
- androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- transcription coactivator activity
- SMAD binding
- ligand-dependent nuclear receptor transcription coactivator activity