Zmiz1 Gene Summary [Mouse]
Predicted to enable SMAD binding activity; SUMO ligase activity; and transcription coactivator activity. Involved in positive regulation of Notch signaling pathway and positive regulation of T cell differentiation. Acts upstream of or within several processes, including circulatory system development; positive regulation of fibroblast proliferation; and vitellogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin. Is expressed in several structures, including early embryo; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in end stage renal disease. Orthologous to human ZMIZ1 (zinc finger MIZ-type containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zmiz1 |
| Official Name | zinc finger, MIZ-type containing 1 [Source:MGI Symbol;Acc:MGI:3040693] |
| Ensembl ID | ENSMUSG00000007817 |
| Bio databases IDs | |
| Aliases | zinc finger, MIZ-type containing 1 |
| Synonyms | E330020C23, Gm10397, I920194n01, LOC102553140, MIZ, NEDDFSA, RAI17, TRAFIP10, ZIMP10, zinc finger MIZ-type containing 1, zinc finger, MIZ-type containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zmiz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- transcription co-activator
- Zmiz1 N-terminal tetratricopeptide repeat domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- metabolic syndrome X
- major depression
- schizophrenia
- epithelial cancer
- cancer
- abdominal cancer
- inflammatory bowel disease
- neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies
- multiple sclerosis
role in cell
- growth
- expression in
- differentiation
- activation in
- proliferation
- colony formation by
- transcription in
- senescence in
- transactivation in
- dexamethasone sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zmiz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vitellogenesis
- protein sumoylation
- SMAD protein signal transduction
- cellular senescence
- pyramidal neuron migration
- transforming growth factor beta receptor signaling pathway
- artery morphogenesis
- vasculogenesis
- developmental growth
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- regulation of transcription from RNA polymerase II promoter
- heart morphogenesis
- in utero embryonic development
- positive regulation of T cell differentiation
- positive regulation of fibroblast proliferation
- androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- transcription coactivator activity
- SMAD binding
- ligand-dependent nuclear receptor transcription coactivator activity