Casc3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within intracellular mRNA localization. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human CASC3 (CASC3 exon junction complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casc3 |
| Official Name | cancer susceptibility candidate 3 [Source:MGI Symbol;Acc:MGI:2179723] |
| Ensembl ID | ENSMUSG00000078676 |
| Bio databases IDs | |
| Aliases | cancer susceptibility candidate 3 |
| Synonyms | Barentsz, BTZ, CASC3 exon junction complex subunit, exon junction complex subunit, MLN 51 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Casc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SELOR module
- ubiquitin protein ligase binding
- CASC3/Barentsz eIF4AIII binding
- enzyme binding
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- spliceosomes
- nucleoplasm
- nuclear envelope
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Casc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- regulation of translation
- intracellular mRNA localization
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- nuclear membrane
- exon-exon junction complex
- perinuclear region of cytoplasm
- cytoplasmic stress granule
- nuclear speck
- U2-type catalytic step 1 spliceosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- ubiquitin protein ligase binding
- mRNA binding
- enzyme binding