Ik Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Predicted to be active in nucleus. Predicted to colocalize with mitotic spindle pole and nuclear chromosome. Is expressed in testis. Orthologous to human IK (IK cytokine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ik |
| Official Name | IK cytokine [Source:MGI Symbol;Acc:MGI:1345142] |
| Ensembl ID | ENSMUSG00000024474 |
| Bio databases IDs | |
| Aliases | IK cytokine |
| Synonyms | CSA2, IFN gamma ANTAGONIST, IFN gamma ANTAGONIST CYTOKINE, IFN γ ANTAGONIST, IFN γ ANTAGONIST CYTOKINE, IK cytokine, IK factor, MuRED, RED, RER |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ik often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RED-like protein C-terminal region
- RED-like protein N-terminal region
- protein binding
- cytokine
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cell viability
- colony formation
- splicing by
- alternative splicing in
- integration in
- integration
- spindle checkpoint in
- mitosis
- homologous recombination in
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- spliceosomes
- chromosome
- nucleoplasm
- spindle pole
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ik gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- protein localization to kinetochore
- mitotic cell cycle
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- nuclear chromosome
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding