PPP2R5C Gene Summary [Human]

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Details

Type
Processed Transcript
Official Symbol
PPP2R5C
Official Name
protein phosphatase 2 regulatory subunit B'gamma [Source:HGNC Symbol;Acc:HGNC:9311]
Ensembl ID
ENSG00000078304
Bio databases IDs NCBI: 5527 Ensembl: ENSG00000078304
Aliases protein phosphatase 2 regulatory subunit B'gamma
Synonyms 2610043M05RIK, 2700063L20Rik, AW545884, B56G, B56gamma, B56 Gamma3, D12Bwg0916e, LOC100040799, LOC102557581, LOC684586, PP2A B' gamma, PP2A B' γ, PR61G, Pr61 γ, protein phosphatase 2 regulatory subunit B'gamma, protein phosphatase 2, regulatory subunit B', gamma, protein phosphatase 2 regulatory subunit B'γ, protein phosphatase 2, regulatory subunit B', γ, RGD1564600
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP2R5C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • peptidase
  • protein phosphatase regulator
  • Protein phosphatase 2A regulatory B subunit (B56 family)
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metabolic syndrome X
  • restless legs syndrome
  • organismal death
  • non-small cell lung carcinoma
  • non-small cell lung cancer
  • metastasis
  • neoplastic cell transformation
  • mental retardation
  • autism
  • vitiligo
regulated by
role in cell
  • phosphorylation in
  • binding in
  • expression in
  • migration
  • motility
  • proliferation
  • survival
  • growth
  • 5-fluorouracil sensitivity
  • apoptosis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Golgi-enriched fraction
  • Cytoplasm
  • cell periphery
  • cellular membrane
  • focal adhesions
  • Golgi Apparatus
  • cytosol
  • Golgi membrane
  • nucleoplasm
  • Z line
  • centromeres

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PPP2R5C gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteasomal ubiquitin-dependent protein catabolic process
  • signal transduction
  • negative regulation of cell proliferation
  • protein dephosphorylation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol
  • Golgi apparatus
  • protein phosphatase type 2A complex
  • chromosome, centromeric region
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein phosphatase activator activity
  • protein phosphatase regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.