POLR3G Gene Summary [Human]
Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | POLR3G |
| Official Name | RNA polymerase III subunit G [Source:HGNC Symbol;Acc:HGNC:30075] |
| Ensembl ID | ENSG00000113356 |
| Bio databases IDs | |
| Aliases | RNA polymerase III subunit G |
| Synonyms | 2310047G20Rik, C31, LOC103691413, LOC682370, polymerase (RNA) III (DNA directed) polypeptide G, RNA polymerase III subunit G, RPC32, RPC32 alpha, RPC32 α, RPC7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR3G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-directed RNA polymerase
- chromatin binding
- enzyme
- protein binding
- DNA-directed RNA polymerase III subunit Rpc31
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- androgenic alopecia
- metastasis
- bladder cancer
- neoplastic cell transformation
role in cell
- growth
- expression in
- migration
- invasion by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR3G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation of innate immune response
- transcription from RNA polymerase III promoter
- positive regulation of interferon-beta production
- innate immune response
- defense response to virus
- regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- DNA-directed RNA polymerase activity
- chromatin binding