WAC Gene Summary [Human]
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | WAC |
| Official Name | WW domain containing adaptor with coiled-coil [Source:HGNC Symbol;Acc:HGNC:17327] |
| Ensembl ID | ENSG00000095787 |
| Bio databases IDs | |
| Aliases | WW domain containing adaptor with coiled-coil |
| Synonyms | 1110067P07Rik, A230035H12RIK, BM-016, DESSH, LOC101056456, PRO1741, RGD1562407, WW domain containing adaptor with coiled-coil, WWP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WAC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- Domain with 2 conserved Trp (W) residues
- WW
- enzyme binding
- chromatin binding
- protein binding
- zDHHC ankyrin repeat binding domain
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- non-insulin-dependent diabetes mellitus
- Desanto-Shinawi syndrome
- covid-19 death
- facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to WAC point mutation
- COVID-19
- Alzheimer disease
- prostate cancer
- hereditary disorder
- tumorigenesis
role in cell
- expression in
- DNA damage response
- remodeling
- invasion by
- alternative splicing in
- lipotoxicity in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WAC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- mitotic cell cycle G1/S transition DNA damage checkpoint
- regulation of autophagy
- response to DNA damage stimulus
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- RNA polymerase II core binding