Rars Gene Summary [Mouse]
Enables arginine-tRNA ligase activity. Involved in arginyl-tRNA aminoacylation. Located in mitochondrion. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rars |
| Official Name | arginyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:1914297] |
| Ensembl ID | ENSMUSG00000018848 |
| Bio databases IDs | |
| Aliases | arginyl-tRNA synthetase |
| Synonyms | 2610011N19Rik, 2610037E21Rik, Arginyl-tRNA synthetase, arginyl-tRNA synthetase 1, ArgRS, bone marrow macrophage tRNA synthetase, Cytoplasmic tRNA Synthetase, DALRD1, HLD9, RARS, RRS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- arginyl-tRNA synthetase
- tRNA synthetases class I (R)
- ATP binding
- enzyme
- protein binding
- amino acid binding
- class Ia aminoacyl tRNA synthetases anticodon binding domain
- binding protein
- DALR anticodon binding domain
- Arginyl tRNA synthetase N terminal domain
- arginine-tRNA ligase
- Arginyl tRNA synthetase N terminal dom
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- abdominal cancer
- non-small cell lung cancer
- COVID-19
- retroperitoneal cancer
- hypomyelinating leukodystrophy type 9
- leukodystrophy
- hereditary disorder
role in cell
- recruitment
- proliferation
- expression in
- production in
- migration
- invasion by
- binding in
- alternative splicing in
- consumption in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- arginyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- arginine binding
- ATP binding
- protein binding
- arginine-tRNA ligase activity
- cadherin binding
- tRNA binding