GON4L Gene Summary [Human]
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within B cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GON4L |
| Official Name | gon-4 like [Source:HGNC Symbol;Acc:HGNC:25973] |
| Ensembl ID | ENSG00000116580 |
| Bio databases IDs | |
| Aliases | gon-4 like, YY1AP related protein |
| Synonyms | 1500041I23Rik, 2610100B20Rik, 3632445O20Rik, 5430404N14Rik, 5830417I10Rik, AA387005, Dingo, FLJ20203, GON-4, gon-4 like, LOC100505728, YARP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GON4L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- transcription co-repressor
- protein binding
- Paired amphipathic helix repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetic retinopathy
- gastric carcinoma
- gastric epithelial cancer
- autosomal recessive nonsyndromic mental retardation
regulated by
- tetradecanoylphorbol acetate
- Gstp1 (includes others)
role in cell
- apoptosis
- expression in
- differentiation
- number
- development
- synthesis in
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GON4L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity