MIIP Gene Summary [Human]
This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Details
| Type | Processed Transcript |
| Official Symbol | MIIP |
| Official Name | migration and invasion inhibitory protein [Source:HGNC Symbol;Acc:HGNC:25715] |
| Ensembl ID | ENSG00000116691 |
| Bio databases IDs | |
| Aliases | migration and invasion inhibitory protein, invasion inhibitory protein 45 |
| Synonyms | D4Wsu114e, IIP45, LOC100911456, migration and invasion inhibitory protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Migration and invasion-inhibitory
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- colorectal cancer
- atopic dermatitis
- glioma formation
- overall survival
role in cell
- expression in
- activation in
- growth
- phosphorylation in
- epithelial-mesenchymal transition
- migration
- binding in
- colony formation
- interaction in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of G2/M transition of mitotic cell cycle
- negative regulation of cell migration
Molecular Function
What the gene product does at the molecular level
- protein binding