CD58 Gene Summary [Human]
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | CD58 |
| Official Name | CD58 molecule [Source:HGNC Symbol;Acc:HGNC:1688] |
| Ensembl ID | ENSG00000116815 |
| Bio databases IDs | |
| Aliases | CD58 molecule |
| Synonyms | Ag3, CD58 molecule, LFA-3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD58 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- ectodomain
- protein binding
- receptor binding
- transmembrane receptor
- glycosylphosphatidylinositol anchor sequence
Pathways
Biological processes and signaling networks where the CD58 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- neoplasia
- adult T-cell leukemia/lymphoma
- diffuse large B-cell lymphoma
- systemic lupus erythematosus
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- primary biliary cirrhosis
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- proliferation
- expression in
- phosphorylation in
- adhesion
- interaction in
- degradation in
- migration
- activation in
- activation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
- secretory granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD58 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interleukin-8 production
- cellular response to tumor necrosis factor
- heterotypic cell-cell adhesion
- cellular response to interferon-gamma
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding