Prex1 Gene Summary [Mouse]
Predicted to enable GTPase regulator activity; phospholipid binding activity; and protein serine/threonine kinase inhibitor activity. Acts upstream of or within several processes, including neutrophil chemotaxis; positive regulation of GTPase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in several cellular components, including dendritic shaft; growth cone; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; nervous system; palatal shelf; skeleton; and testis. Used to study autism spectrum disorder. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prex1 |
| Official Name | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [Source:MGI Symbol;Acc:MGI:3040696] |
| Ensembl ID | ENSMUSG00000039621 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
| Synonyms | G630042G04, LOC105372648, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1, PREX1 isoform 1, RGD1306534, Setd6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prex1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- phospholipid binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- DEP
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Prex1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- Alzheimer disease
- colorectal cancer
- postmenopausal osteoporosis
- experimentally induced airway hyperresponsiveness
- pervasive developmental disorder
- colorectal adenoma
- colorectal adenoma formation
- plasma cell myeloma
role in cell
- apoptosis
- cell viability
- phosphorylation in
- expression in
- formation
- formation in
- cellular infiltration by
- transmigration
- motility
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- neurite stump
- growth cone
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prex1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutrophil activation
- G-protein coupled receptor signaling pathway
- actin filament polymerization
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of GTPase activity
- regulation of actin filament polymerization
- T cell differentiation
- regulation of dendrite development
- superoxide metabolic process
- regulation of signaling
- regulation of small GTPase mediated signal transduction
- neutrophil chemotaxis
- intracellular signal transduction
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- growth cone
- perinuclear region of cytoplasm
- dendritic shaft
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- phospholipid binding
- enzyme binding