UXT Gene Summary [Human]
The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | UXT |
| Official Name | ubiquitously expressed prefoldin like chaperone [Source:HGNC Symbol;Acc:HGNC:12641] |
| Ensembl ID | ENSG00000126756 |
| Bio databases IDs | |
| Aliases | ubiquitously expressed prefoldin like chaperone, androgen receptor trapped clone 27, SKP2-associated alpha PFD 1 |
| Synonyms | 0910002B17Rik, ART-27, SKP2, STAP1, ubiquitously expressed prefoldin like chaperone, ubiquitously-expressed, prefoldin-like chaperone |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UXT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- microtubule binding
- transcription regulator
- prefoldin
- transcription co-repressor
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic autoimmune syndrome
role in cell
- proliferation
- cell death
- apoptosis
- expression in
- differentiation
- suppressive capacity
- organization
- disassembly
- depolarization
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- perinuclear region
- Nucleus
- centrosome
- nucleoplasm
- spindle pole
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UXT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- centrosome cycle
- mitochondrion transport along microtubule
- apoptotic process
- microtubule cytoskeleton organization
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoskeleton
- cytoplasm
- spindle pole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- transcription corepressor activity
- beta-tubulin binding
- chromatin binding
- microtubule binding