E2F8 Gene Summary [Human]
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | E2F8 |
| Official Name | E2F transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24727] |
| Ensembl ID | ENSG00000129173 |
| Bio databases IDs | |
| Aliases | E2F transcription factor 8 |
| Synonyms | 4432406C08RIK, AA410048, E2F transcription factor 8, RGD1308091 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human E2F8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- E2F/DP family winged-helix DNA-binding domain
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- identical protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the E2F8 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cell Cycle Regulation by BTG Family Proteins
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- lymphomagenesis
- B cell cancer
- bleeding
- tumorigenesis
- lung squamous cell carcinoma
- squamous cell lung cancer
- hepatocellular carcinoma
- breast carcinoma
role in cell
- apoptosis
- expression in
- binding in
- proliferation
- colony formation
- migration
- transactivation in
- differentiation
- polyploidization
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human E2F8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sprouting angiogenesis
- positive regulation of transcription from RNA polymerase II promoter
- placenta development
- regulation of transcription from RNA polymerase II promoter
- fibroblast proliferation
- negative regulation of transcription from RNA polymerase II promoter
- hepatocyte differentiation
- chorionic trophoblast cell differentiation
- trophoblast giant cell differentiation
- cell cycle comprising mitosis without cytokinesis
- negative regulation of cytokinesis
- positive regulation of DNA endoreduplication
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity