CCNL2 Gene Summary [Human]
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Retained Intron |
| Official Symbol | CCNL2 |
| Official Name | cyclin L2 [Source:HGNC Symbol;Acc:HGNC:20570] |
| Ensembl ID | ENSG00000221978 |
| Bio databases IDs | |
| Aliases | cyclin L2, cyclin S |
| Synonyms | 1700010A01RIK, 1810019L15Rik, 2010319M22Rik, AI428898, ANIA-6B, CCNM, CCNS, Cyclin Ania6b, cyclin L2, HCLA-150, HCLA-ISO, HLA-ISO, PCEE, SB138 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclin box fold superfamily
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCNL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
- regulation of apoptotic process
- regulation of cell cycle
- regulation of centrosome cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- nuclear speck
- cyclin-dependent protein kinase holoenzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclin-dependent protein kinase regulator activity
- protein binding