GALR3 Gene Summary [Human]
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GALR3 |
| Official Name | galanin receptor 3 [Source:HGNC Symbol;Acc:HGNC:4134] |
| Ensembl ID | ENSG00000128310 |
| Bio databases IDs | |
| Aliases | galanin receptor 3 |
| Synonyms | galanin receptor 3, Galnr3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GALR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- galanin receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the GALR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- obesity
- Parkinson disease
- polycystic ovary syndrome
regulates
- cholesterol
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- triacylglycerol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- non-motile cilium
- cilia
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GALR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- feeding behavior
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- learning or memory
Cellular Component
Where in the cell the gene product is active
- membrane
- cilium
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- galanin receptor activity
- peptide hormone binding